Mongol rule in China provoked a native reation in 1368, which brought the Ming dynasty to power with its capital at Nanking.

Early in the Ming period (1405-33) naval expeditions, led by admiral Cheng Ho, opened new trade routes to Southeast Asia and the Persian Gulf.

But mindful of previous Mongol invasions the Mings moved the capital back to  Peking ( = capital of the North) to improve the defense of the northern frontier.
The security of the empire was again paramount, trading activities became secondary, and all naval expedtions were stopped.

Ming China reacted to the advances of Europeans, the incursion of the Mongols and Japanese pirates with increasing isolationism.

Ming China
Summary :
Mongol rule over China weakens.
Rebellion by Chinese and the first Ming emperor.
Naval voyages followed by isolationism.